The expression of normal motor-related functional pattern using fMRI and PET in sporadic dystonia

Normal motor-related pattern (NMRP) was originally identified in H215O PET study by multivariate analysis based on principal component analysis, and found to be more strongly expressed in patients with DYT1 dystonia than normal controls. Studying a group of subjects with both fMRI and PET, we derived NMRP from each imaging modality. We then applied the pattern in a group of sporadic dystonia patients. We found that sporadic dystonia patients did not have elevated NMRP expression, hence the increase previously seen in DYT1 dystonia patients may have genetic causes.

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