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Abstract #3514

Correlation of quantitative MRI and histology of surgical specimens in drug-resistant focal epilepsy

Maged Goubran 1 , Robert R. Hammond 2 , Sandrine de Ribaupierre 3 , Terry M. Peters 1 , and Ali R. Khan 1

1 Imaging Laboratories, Robarts Research Institute, London, Ontario, Canada, 2 Department of Pathology, Western university, London, Ontario, Canada, 3 Department of Clinical Neurological Sciences, Western university, London, Ontario, Canada

The pathological basis of abnormal MRI signals is poorly understood in focal epilepsy and correlation between histology and pre-operative MRI is needed. Our objective is to correlate quantitative in-vivo MR sequences and histology of surgical specimens from drug-resistant temporal lobe epilepsy patients. This study is the first to assess the relation between MRI and histology using correspondences based on image registration. By means of quantitative MRI metrics and histological features we demonstrated a significant correlation between T1 values and neuronal density in the grey matter. This correlation could subsequently allow prediction of pathology from in-vivo imaging.

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