Diffusion Tensor Imaging for White Matter Alterations in Chronic Cocaine Dependents

Neuronal dysfunctions associated with cocaine additions have been wildly reported inside and outside the dopaminergic reward system, yet the structural basis for the abnormal circuitry responses is still unclear. A diffusion tensor imaging (DTI) study was performed using relatively larger group size and more comprehensive subject characterizations to investigate the white matter (WM) alteration patterns in chronic cocaine users. Our data show a complex DTI alteration pattern across multiple regions inside and outside the dopaminergic system.

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