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Abstract #3519

In vivo MRI evidence of cranial nerve inflammation after corneal damage

Linda Chaabane 1 , Fabio Bignami 2 , Chiara Giacomini 2 , Eleonora Capitolo 1 , Paolo Rama 2 , Giulio Ferrari 2 , and Giancarlo Comi 1

1 INSPE, Div. Neuroscience, San Raffaele Scientific Institute, Milano, Italy, 2 Cornea and Ocular Surface Unit, San Raffaele Scientific Institute, Italy

This study was designed to put in evidence the inflammatory activity within a cranial nerve, the trigeminal ganglion, induced by a peripheral damage of the cornea. In vivo MRI in combination with uspio contrast allowed the evidence of uspio uptake in the trigeminal ganglion far away from the site of injury (cornea) which correlated to specific inflammatory cells positive to immuno-markers of M2 macrophages.

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