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Abstract #3529

Quantification of lung microstructure in asthma using a 3 He fractional diffusion approach

Juan Parra-Robles 1 , Helen Marshall 1 , Ruth A Hartley 2 , Christopher E Brightling 2 , and Jim M Wild 1

1 Unit of Academic Radiology, University of Sheffield, Sheffield, United Kingdom, 2 Institute for Lung Health, University of Leicester, Leicester, United Kingdom

In this work, a new approach based on a fractional diffusion model is developed to allow for in-vivo estimation of the distributions of the microscopic length scales of acinar airways from 3 He diffusion MRI data. This new technique is used to assess the acinar microstructure in asthma patients and the results are compared with CT densitometry and macroscopic 3 He ventilation distributions.

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