Abstract #3530
Bronchodilatation Effect on Lung Function of Asthma Patients Measured by Static and Dynamic 3He MRI: First Results of Clinical Trial
Maxim Terekhov 1 , Ursula Wolf 2 , Klaus K Gast 2 , Christian Hoffmann 2 , Nina Bojadzic 2 , Sergei Karpuk 3 , Christian Mrozik 3 , Christoph Dber 2 , and Laura Maria Schreiber 1
1
Section of Medical Physics, Department of
Radiology, Johannes Gutenberg University Medical Center
Mainz, Mainz, Germany,
2
Department
of Radiology, Johannes Gutenberg University Medical
Center Mainz, Mainz, Germany,
3
Institute
of Physics, Johannes Gutenberg University Mainz, Mainz,
Germany
Static and Dynamic Ventilation of lungs measured with
hyperpolarized 3He-MRI are efficient tools to visualize
and quantify the lung ventilation and intrapulmonary gas
inflow. Ventilation measurements give information on
both spatial and temporal distribution of gas in airways
and parenchyma being of great importance for the
diagnostics of airways obstruction diseases e.g. asthma
and COPD. Measurements of static and dynamic lung
ventilation with HP-3He-MRI were performed on bronchial
asthma patients before and after bronchodilatation in
order find out if the BD-effect can be detected using
3He-MRI and to correlate the variation of measured
parameters with the spirometry tests.
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