Abstract #3533
Assessing the Diagnostic Power of a Hybrid Combination of Hyperpolarized 3 He MRI derived ADC, Specific Ventilation and Alveolar Oxygen Tension in COPDs
Hooman Hamedani 1 , Stephen Kadlecek 1 , Masaru Ishii 2 , Yi Xin 1 , Hoora Shaghaghi 1 , Biao Han 1 , Sarmad Siddiqui 1 , Milton Rossman 1 , and Rahim R. Rizi 1
1
University of Pennsylvania, Philadelphia,
PA, United States,
2
Johns
Hopkins University, Merryland, United States
The hybrid multibreath
3
He
imaging technique has been previously used to measure
regional lung parameters such as p
A
O
2
,
specific ventilation (SV) and ADC measurements
simultaneously. The combination of these three imaging
measurements effectively probes the different aspects of
lung disease in a manner analogous to current clinical
measurements. The obtained measurements are highly
correlated with conventional pulmonary tests (pulmonary
function test, six-minute walk test, and the St.
Georges Questionnaire). In this study, the p
A
O
2
,
SV and ADC measurements acquired using the hybrid
technique were assessed for their viability as markers
for distinguishing between smokers and nonsmokers.
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