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Abstract #3533

Assessing the Diagnostic Power of a Hybrid Combination of Hyperpolarized 3 He MRI derived ADC, Specific Ventilation and Alveolar Oxygen Tension in COPDs

Hooman Hamedani 1 , Stephen Kadlecek 1 , Masaru Ishii 2 , Yi Xin 1 , Hoora Shaghaghi 1 , Biao Han 1 , Sarmad Siddiqui 1 , Milton Rossman 1 , and Rahim R. Rizi 1

1 University of Pennsylvania, Philadelphia, PA, United States, 2 Johns Hopkins University, Merryland, United States

The hybrid multibreath 3 He imaging technique has been previously used to measure regional lung parameters such as p A O 2 , specific ventilation (SV) and ADC measurements simultaneously. The combination of these three imaging measurements effectively probes the different aspects of lung disease in a manner analogous to current clinical measurements. The obtained measurements are highly correlated with conventional pulmonary tests (pulmonary function test, six-minute walk test, and the St. Georges Questionnaire). In this study, the p A O 2 , SV and ADC measurements acquired using the hybrid technique were assessed for their viability as markers for distinguishing between smokers and nonsmokers.

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