SPECTROSCOPY OF DISSOLVED 129 Xe IN HUMAN BRAIN AT 1.5T

Hyperpolarized 129Xe has large range of chemical shift and can be used to study the human brain when 129Xe dissolved in the blood is transferred to white matter, grey matter and cerebral lipids. In this work we demonstrate in vivo human brain spectroscopy with dissolved 129Xe at 1.5T. In addition to peaks from grey and white matter, we detected peaks from 129Xe in red blood cells and lipids in the brain. We have established optimal topology for RF coils for 129Xe brain spectroscopy and developed a model for dissolved xenon blood uptake from the lungs to the brain.

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