Abstract #3540
Comparison of Normalized T1 and Pulmonary Blood Flow Assessments in Cystic Fibrosis Lung Disease
Lan Lu 1,2 , Shannon Donnola 1 , Elliott C Dasenbrook 3 , David Weaver 3 , Michael W Konstan 3 , and Chris A Flask 1,4
1
Department of Radiology, Case Western
Reserve University, Cleveland, OH, United States,
2
Department
of Urology, Case Western Reserve University, Cleveland,
OH, United States,
3
Department
of Pediatrics, Case Western Reserve University,
Cleveland, OH, United States,
4
Department
of Biomedical Engineering, Case Western Reserve
University, Cleveland, OH, United States
We have previously developed a normalized T1 (nT1)
method to sensitively and rapidly detect early-stage
lung disease in cystic fibrosis (CF) patients. In this
study, we aimed to determine the mechanism underlying
observed nT1 changes in CF patients by direct comparison
with pulmonary perfusion assessed by Arterial Spin
Labeling. ASL and nT1 assessments in nine CF patients
demonstrated significantly reduced mean nT1 and
pulmonary perfusion in the upper lungs in comparison to
healthy controls. A significant correlation (p <0.05)
was also observed between nT1 and pulmonary perfusion.
These results suggest that the nT1 technique is related
to pulmonary perfusion.
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