Abstract #3541
Quantitative Gadolinium-based Aerosol Deposition and Dynamics in Healthy Rat Lung by UTE-MRI
Hongchen Wang 1 , Catherine Sbri 1 , Jean-Pierre Ruaud 1 , Genevive Guillot 1 , Khaoula Bouazizi-Verdier 1 , Georges Willoquet 1 , Xavier Matre 1 , Luc Darrasse 1 , and Ludovic de Rochefort 1
1
Imagerie par Rsonance Magntique Mdicale
et Multi-Modalits (UMR8081) IR4M, CNRS, Univ.
Paris-Sud, Orsay, France
Aerosol toxicology and drug delivery through the lungs
require the development of methods to quantify particle
deposition. The use of intrapulmonary-administered MRI
contrast agent combined to lung-specific imaging
sequences has been proposed and remains an active
preclinical research topic. Various administration
protocols and pulse sequences have been used, and more
recently ultra-short echo (UTE) sequences that are more
adapted for lung parenchyma imaging. Here, we present
the use of 3D UTE implemented in a clinical scanner,
performed pre- and post- administration of
gadolinium-based aerosol delivery in spontaneously
breathing healthy rats, thus mimicking chronic particle
exposure or free-breathing drug delivery. The
contrast-enhanced quantification method enabled us to
follow up lung clearance and regional heterogeneity in
the deposition.
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