Abstract #3554
4D contrast enhanced MRI of the developing mouse kidney
Luke Xie 1,2 , Ergys Subashi 2,3 , Yi Qi 2 , and G. Allan Johnson 1,2
1
Biomedical Engineering, Duke University,
Durham, North Carolina, United States,
2
Center
for In Vivo Microscopy, Radiology, Duke University
Medical Center, Durham, North Carolina, United States,
3
Medical
Physics Graduate Program, Duke University Medical
Center, Durham, North Carolina, United States
We acquired high spatiotemporal resolution datasets of
the developing mouse kidney. The data were acquired with
a cryogenic surface coil and a dynamic contrast enhanced
(DCE) MRI sequence, allowing 3D images (125
3
μm
3
)
to be obtained every 7.7 sec over a 50-min scan (390
time points). The DCE curves were used to determine a 3D
time-to-peak map (time of injection to peak
enhancement). Time-to-peak values and volumes were
determined in three renal regionscortex, outer medulla,
and inner medulla. These functional and structural
changes were measured over 17 weeks at 6 points (3, 5,
7, 9, 13, 17 weeks).
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