Sensitivity of Arterial Spin Labeling Perfusion Imaging to Pharmacologically Induced Changes in the Rat Kidneys
Huan Tan 1 , Jon Thacker 2 , Tammy Franklin 3 , and Pottumarthi V Prasad 1,3
University of Chicago, Chicago, IL, United
University, Evanston, IL, United States,
University HealthSystem, Evanston, IL, United States
The objective of this study was to investigate whether
arterial spin labeling (ASL) MRI in rat kidneys can be
sensitive to pharmacologically induced vasodilation and
vasoconstriction. The preliminary results demonstrated
the sensitivity of ASL to changes in renal cortical
perfusion and showed the estimates to be reproducible
(with adenosine) and cumulative (with L-NAME).
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