Abstract #3563
Intra-tumoral Heterogeneity in Tumor Vascularity Correlates with ADC Quantification in Renal Masses
Qing Yuan 1 , Koji Sagiyama 2 , Yue Zhang 1 , Naira Muradyan 3 , Annanth Madhuranthakam 1,2 , Yin Xi 1 , Ivan E Dimitrov 2,4 , Vitaly Margulis 5 , James Brugarolas 6,7 , Payal Kapur 5,8 , and Ivan Pedrosa 1,2
1
Radiology, UT Southwestern Medical Center,
Dallas, TX, United States,
2
Advanced
Imaging Research Center, UT Southwestern Medical Center,
Dallas, TX, United States,
3
iCAD,
Inc., Nashua, NH, United States,
4
Philips
Medical Systems, Cleveland, OH, United States,
5
Urology,
UT Southwestern Medical Center, Dallas, TX, United
States,
6
Internal
Medicine, UT Southwestern Medical Center, Dallas, TX,
United States,
7
Developmental
Biology, UT Southwestern Medical Center, Dallas, TX,
United States,
8
Pathology,
UT Southwestern Medical Center, Dallas, TX, United
States
The purpose of this study is to investigate the
correlation between the in vivo heterogeneity in tumor
perfusion and cellularity in renal masses using dynamic
contrast-enhanced (DCE) and diffusion-weighted imaging
(DWI) techniques. Quantitative DCE and DWI parameters
were obtained from the whole tumor, and from areas with
high- and low-enhancement in the tumor. High-enhancement
tumor regions demonstrated significant higher perfusion
measures as well as lower ADC values. Our results
confirm the correlation between intra-tumoral
heterogeneity in blood flow and ADC in patients with
renal masses.
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