Abstract #3576
Magnetic Resonance Imaging Evaluation of the Adaptive Response of the Contralateral Kidney Following Nephrectomy in Patients with Renal Cell Carcinoma
Mao-Yuan Marine Su 1 , Kuo-How Huang 2 , Chin-Chen Chang 1 , Vin-Cent Wu 3 , Wen-Chau Wu 4 , Kao-Lang Liu 1 , and Wen-Yih Isaac Tseng 1,5
1
Department of Medical Imaging, National
Taiwan University Hospital, Taipei, Taiwan,
2
Department
of Urology, National Taiwan University Hospital, Taipei,
Taiwan,
3
Department
of Internal Medicine, National Taiwan University
Hospital, Taipei, Taiwan,
4
Graduate
Institute of Oncology, National Taiwan University,
Taipei, Taiwan,
5
Center
for Optoelectronic Medicine, National Taiwan University
College of Medicine, Taipei, Taiwan
This study aimed to evaluate the adaptive responses of
the contralateral kidney in patients with renal cell
carcinoma (RCC) following radical nephrectomy (RN).
Eleven patients with RCC scheduled for RN and 15 control
patients scheduled for adrenalectomy (Control) were
prospectively studied. All the subjects underwent 4 MRI
studies: 1 before surgery and 3 at 1 week, 1 month and 3
months after surgery, respectively. Our results
indicated that RN in patients with RCC results in an
early increase in renal blood flow (RBF) of the
contralateral kidney. At 3 months, the patients showed
normalization of the RBF, accompanied by compensatory
renal hypertrophy. In patients with reduced renal mass,
an early increase in RBF was associated with late renal
hypertrophy. Therefore, given healthy conditions of the
kidneys at baseline, we might be able to predict the
late renal function of the contralateral kidney based on
its early response to RBF.
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