Usefulness of a 3D Dual-Flip-angle T1 mapping technique pre and post Gadoxetic acid administration for the Assessment of Diffuse Liver Disease

The purpose of this study was to assess the diagnostic value of a novel 3D FLASH dual-flip-angle (DFA) T1 mapping sequence with whole liver coverage, used before and after injection of gadoxetic acid for the evaluation of diffuse liver disease. We found significantly lower T1 at hepatobiliary phase and lower T1 changes (ΔT1) in cirrhotic patients compared with non-cirrhotic patients, and between Child Pugh B+C in comparison with Child Pugh A patients. 3D T1 mapping sequence with whole liver coverage used before and after gadoxetic acid injection can help detect cirrhosis and evaluate liver function.

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