Abstract #3592
Feasibility and Reproducibility of R2* Measurement Under Oxygen and Carbogen Challenge in Healthy Subjects and Patients with Hepatocellular Carcinoma at 1.5 T and 3T
Octavia Bane 1 , Cecilia Besa 1 , Niels Oesingmann 2 , Hadrien Dyvorne 3 , Guido Jajamovich 1 , Marcelo Facciutto 4 , Sasan Roayaie 4 , and Bachir Taouli 1
1
Translational and Molecular Imaging
Institute, Icahn School of Medicine at Mount Sinai
Hospital, New York, NY, United States,
2
US
MR Division R&D, Siemens Healthcare, New York, NY,
United States,
3
ranslational
and Molecular Imaging Institute, Icahn School of
Medicine at Mount Sinai Hospital, New York, NY, United
States,
4
Transplant
Institute, Icahn School of Medicine at Mount Sinai
Hospital, New York, NY, United States
Measurement of the transverse magnetization relaxation
rate (R2*) is of great interest as a potential
non-invasive marker of tumor oxygenation. The purpose of
our study was to quantify R2* at baseline and after
hyperoxic and hyperoxic-hypercapnic respiratory
challenges, in hepatocellular carcinoma (HCC) lesions,
liver and muscle. R2* measurements were reproducible
within a 15% coefficient of variation at 1.5T for all
tissues and gas challenges studied, but showed greater
variability at 3T. The response of HCC lesions to oxygen
and carbogen challenge, quantified by change in R2*, was
highly variable, and will be correlated with pathologic
findings in a future study.
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