Abstract #3602

In vivo assessment of skeletal muscle ATP synthesis in Ob/Ob mice

Patricia Maria Nunes ¹ , Barbara Janssen ¹ , Andor Veltien ¹ , Henk Arnts ² , Cees Tack ³ , and Arend Heeschap ¹

¹ Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands, ² Central Animal Laboratory, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands, ³ Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands

Caloric overload stresses energy homeostasis maintenance in key metabolic tissues as the skeletal muscle. This phenomenon is, in the long run, characterized by intramyocellular lipid accumulation and impaired oxidative capacity. We tested in leptin deficient mice (Ob/Ob) mice whether ATP synthesis was impaired, by means of 31 P MRS. The overall muscular Pi right arrow

ATP flux assessed with ST showed no differences between WT and Ob/Ob mice, despite greater Pi concentration. When stimulated, muscles of Ob/Ob mice produced lower force and were prone to fatigue. Preliminary data suggests that Ob/Ob mice have higher mitochondrial ATP synthesis, as alluded by the PCr recovery curves.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.