Abstract #3603
Hepatic energy levels are not altered by fructose feeding in mice
Patricia Maria Nunes 1 , Andreas Boss 2 , Alan Wright 1 , Andor Veltien 1 , Cees Tack 3 , John Jones 4 , and Arend Heeschap 1
1
Radiology, Radboud University Nijmegen
Medical Centre, Nijmegen, Gelderland, Netherlands,
2
Radiology,
Radboud University Nijmegen Medical Centre, Gelderland,
Netherlands,
3
Internal
Medicine, Radboud University Nijmegen Medical Centre,
Nijmegen, Gelderland, Netherlands,
4
Life
sciences, Centre for Neurosciences and Cell Biology,
Coimbra, Portugal
Excess fructose consumption has been associated with
poor hepatic ATP synthesis. Yet it is unclear whether a
chronic supply of fructose can
per
se
compromise hepatic ATP homeostasis. Furthermore,
the deleterious effects attributed to fructose do not
seem disassociated from increased caloric intake. Thus,
we assessed throughout 6 weeks, the hepatic high energy
content of mice fed fructose or its isocaloric
equivalent glucose, with 31P MRSI. Our results support
that fructose feeding is not sufficient to alter hepatic
ATP levels, differently from glucose. However it does
increase more rapidly hepatic lipid content.
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