Abstract #3604
Resting acetylcarnitine concentration in skeletal muscle, as measured with long TE 1H-MRS, is associated with insulin sensitivity
Lucas Lindeboom 1 , Christine Nabuurs 1 , Joris Hoeks 2 , Maarten Vosselman 2 , Bram Brouwers 2 , Tineke van de Weijer 1 , Silvie Timmers 2 , Esther Phielix 2 , Eline Kooi 1 , Matthijs Hesselink 3 , Joachim Wildberger 1 , Patrick Schrauwen 2 , and Vera Schrauwen-Hinderling 1
1
Dept. of Radiology, MUMC+, Maastricht,
Netherlands,
2
Dept.
of Human Biology, MUMC+, Maastricht, Netherlands,
3
Dept.
of Human Movement Sciences, MUMC+, Maastricht,
Netherlands
The use of long TE in 1H-MRS enhances the visibility of
the acetylcarnitine peak at 2.13 ppm. In this study we
measured acetylcarnitine concentration in four groups,
chosen to cover the whole range of metabolic health,
from type 2 diabetic patients to endurance trained
athletes. We found lower acetylcarnitine concentrations
in subjects with lower insulin sensitivity. These
results may indicate that T2DM subjects have a lower
ability to form acetylcarnitine, possibly underlying a
decreased insulin sensitivity and metabolic flexibility.
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