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Abstract #3605

Water fat separated MRI during cooling-reheating for the estimation of brown fat amount and activity

Elin Lundstrm 1 , Lars Johansson 1,2 , Peter Bergsten 3 , Hkan Ahlstrm 1 , and Joel Kullberg 1

1 Department of Radiology, Uppsala University, Uppsala, Sweden, 2 AstraZeneca, R&D Mlndal, Sweden, 3 Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

The purpose of this work was two-fold: 1) To evaluate the effect of 3h cooling on human cervical-supraclavicular adipose tissue fat fraction (FF) and R2* 2) To evaluate the potential of a cooling-reheating water-fat MRI protocol for assessing brown adipose tissue (BAT) amount and activity. Imaging was performed in nine volunteers (22-37 years, 5 males). A general decrease in FF following 3h cold exposure was observed, which confirms results from previous PET/CT-studies. By adding a reheating timepoint to the cold exposure protocol, the BAT activity in terms of intracellular lipid consumption could potentially be separated from perfusion effects.

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