Effect of caloric and non-caloric sweeteners on liver lipid metabolism in rats

Excessive use of caloric sweeteners such as glucose and fructose causes hepatic steatosis and obesity. To sweeten food and drinks without the excessive calories, non-caloric sweeteners can be used. In this study lipid metabolism in the liver of rats receiving different caloric and non-caloric sweeteners is examined using ¹ H-[ ¹³ C] MRS combined with the administration of ¹³ C-labeled lipids. The non-caloric sweetener aspartame did not have any effect on liver lipid content or metabolism. In contrast, carbohydrate consumption resulted in increased liver lipid content, which was not accompanied by an increased uptake of dietary lipids and is thus likely caused by increased lipogenesis.

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