Investigation of intrahepatic fat and liver glycogen in diet induced fatty liver disease model

Hepatic hyperlipidemia and hepatic glycogen content in insulin resistant non-alcoholic fatty liver model will help in understanding the early metabolic changes in liver metabolism. In this study we have evaluated the liver fat and glycogen content in non-alcoholic fatty liver using a diet induced insulin resistant rat model and compared with normal liver by in vivo and ex vivo MRS. Our preliminary studies show that the reduction in glycogen content in fatty liver compared to normal liver might be due to low glycogen synthase defects under hyperlipidemia and insulin resistant condition. Liver fat content in fatty liver is inversely correlated with glycogen indicating the impairment in glycogen synthesis due to lipotoxicity.

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