Abstract #3618
Monitoring of Rat Liver Regeneration following Portal Vein Ligation using MR Volumetry and Hepatic Arterial Spin Labelling
Rajiv Ramasawmy* 1,2 , Manil Chouhan* 1,3 , Dipok Kumar Dhar 4 , Adrienne E. Campbell-Washburn 5 , Jack Anthony Wells 1 , Rosamund Barbara Pedley 2 , Massimo Malago 3 , Raj Mookerjee 4 , Stuart A. Taylor 3 , Mark Francis Lythgoe 1 , and Simon Walker-Samuel 1
1
Centre for Advanced Biomedical Imaging,
University College London, London, Greater London,
United Kingdom,
2
Cancer
Institute, University College London, London, Greater
London, United Kingdom,
3
Centre
for Medical Imaging, University College London, London,
Greater London, United Kingdom,
4
Institute for
Liver and Digestive Health, University College London,
London, Greater London, United Kingdom,
5
National
Heart Lung and Blood Institute, National Institutes of
Health, Bethesda, MD, United States
Recently developed surgical procedures utilise the
livers unique regenerational properties to promote lobe
growth prior to curative partial hepatectomy in patients
with liver malignancies. MRI offers accurate,
non-invasive characterisation of anatomical changes,
furthermore it can utilise perfusion imaging to
functionally assess the proposed post-surgery liver
remnant. This study monitored gross lobe changes in a
novel rat model of liver regeneration using
high-resolution anatomical MRI and applied hepatic
arterial spin labelling to evaluate tissue viability.
One week after selective PVL surgery, average lobe
hypertrophy was 74% and average lobe atrophy was -43%
from typical volume. A perfusion difference was observed
between the atrophic and hypertrophic liver lobes.
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