Combined DWI and DCE-MRI of hepatocellular carcinoma: correlation of perfusion and diffusion parameters. Initial experience.

This study assesses diffusion and perfusion characteristics of hepatocellular carcinoma (HCC) and background liver parenchyma measured through the use of both DWI and DCE-MRI acquisition techniques. Semi-quantitative DCE-MRI parameters time to peak (TTP), slope and area under the curve at 60s (AUC60) and DWI parameters apparent diffusion coefficient (ADC) and true diffusion coefficient (D) demonstrated significant differences in HCC vs. liver parenchyma. There was no correlation between DWI and DCE-MRI metrics. These results suggest that the combination of DWI and DCE-MRI in a multiparametric MRI scan provides non-redundant information about HCC tumor biology.

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