Combined DWI and DCE-MRI of hepatocellular carcinoma: correlation of perfusion and diffusion parameters. Initial experience.
Guido Hugo Jajamovich 1 , Hadrien Dyvorne 1 , Cecilia Besa 1 , and Bachir Taouli 1
Icahn School of Medicine at Mount Sinai, New
York, NY, United States
This study assesses diffusion and perfusion
characteristics of hepatocellular carcinoma (HCC) and
background liver parenchyma measured through the use of
both DWI and DCE-MRI acquisition techniques.
Semi-quantitative DCE-MRI parameters time to peak (TTP),
slope and area under the curve at 60s (AUC60) and DWI
parameters apparent diffusion coefficient (ADC) and true
diffusion coefficient (D) demonstrated significant
differences in HCC vs. liver parenchyma. There was no
correlation between DWI and DCE-MRI metrics. These
results suggest that the combination of DWI and DCE-MRI
in a multiparametric MRI scan provides non-redundant
information about HCC tumor biology.
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