Qualitative and Quantitative effects of Gadoxetate Disodium on DWI/ADC in a Healthy, Liver Donor Population

Qualitative and quantitative impact on the liver DWI in the presence of a hepatobiliary contrast agent has been reported to be insignificant. However, our observation contradicts those findings. A year-long trial with over 25 healthy liver donor patients showed a significant change in the b-maps and ADC values in the pre- and post-gadoxetate disodium DWI. In particular, the signal drop was significantly higher post contrast when an inversion recovery (IR) pulse was added for fat suppression. Thus, we suggest that liver DWI should be performed pre-contrast when possible, or without an IR pulse post-contrast.

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