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Abstract #3630

Optimizing b-value distribution for IVIM imaging using adjusted weighting factors

Sonia Isabel Goncalves 1 , Goncalo Cachola 2 , Filipe Caseiro-Alves 3,4 , and Miguel Castelo-Branco 1

1 IBILI-Faculty of Medicine, University of Coimbra, Coimbra, Coimbra, Portugal, 2 Faculty of Sciences and Technology, Universidade Nova de Lisboa, Setubal, Portugal, 3 Faculty of Medicine, University of Coimbra, Coimbra, Portugal, 4 Radiology, University Hospital Coimbra, Coimbra, Portugal

Intra-voxel incoherent motion (IVIM) imaging differentiates between true molecular diffusion, diffusion due to perfusion, and quantifies perfusion fraction. Results from its clinical application have been ambiguous and this can be, at least in part, explained by the dependence of IVIM parameter estimation on the choice of b-value combination that is used to sample the data. In this paper we explore the influence of the perfusion rate regime in the total error propagated into IVIM diffusion/perfusion parameters, in order to optimize the b-value distribution that is used to sample the data.

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