Effect of secretin stimulation in healthy volunteers at 3T: comparison of mono- and biexponential (IVIM) models in pancreas diffusion-weighted imaging
Julie Absil 1 , Helena Torrao 1 , Thierry Metens 1 , Monia Bali 1 , and Celso Matos 1
MRI Unit - Radiology, CUB Hpital Erasme,
Brussels, Brussels, Belgium
In this IRB approved study, the quantification of
Intravoxel Incoherent Motion (IVIM) parameters as well
as monoexponential DWI parameters was performed in
healthy pancreas in order to assess changes during
secretin stimulation. Fifteen healthy volunteers
underwent 3T diffusion-weighted SE-EPI MRI before and at
3 and 8 minutes following secretin injection (1CU/KgBW).
Monoexponential apparent diffusion coefficients
(calculated with different sets of b-values) as well as
IVIM perfusion fraction significantly increased at 3
minutes after secretin administration, reflecting the
expected increase in both perfusion and the exocrine
free water release. All parameters decreased between 3
and 8 minutes after secretin administration.
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