Effect of secretin stimulation in healthy volunteers at 3T: comparison of mono- and biexponential (IVIM) models in pancreas diffusion-weighted imaging

In this IRB approved study, the quantification of Intravoxel Incoherent Motion (IVIM) parameters as well as monoexponential DWI parameters was performed in healthy pancreas in order to assess changes during secretin stimulation. Fifteen healthy volunteers underwent 3T diffusion-weighted SE-EPI MRI before and at 3 and 8 minutes following secretin injection (1CU/KgBW). Monoexponential apparent diffusion coefficients (calculated with different sets of b-values) as well as IVIM perfusion fraction significantly increased at 3 minutes after secretin administration, reflecting the expected increase in both perfusion and the exocrine free water release. All parameters decreased between 3 and 8 minutes after secretin administration.

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