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Abstract #3667

Motion correction of high temporal 3T Dynamic Contrast Enhanced MRI of pancreatic cancer - preliminary results

R. Klaassen 1,2 , O. J. Gurney-Champion 3 , E. G.W. ter Voert 4 , A. Heerschap 4 , M. F. Bijlsma 2 , M. G.H. Besselink 5 , G. van Tienhoven 6 , C. Y. Nio 3 , J. Stoker 3 , C. J.A. Punt 1 , J. W. Wilmink 1 , H. W.M. van Laarhoven 1 , and A. J. Nederveen 3

1 Department of Medical Oncology, Academic Medical Center - University of Amsterdam, Amsterdam, Netherlands, 2 Department of Experimental Oncology and Radiation Biology, Academic Medical Center - University of Amsterdam, Amsterdam, Netherlands, 3 Department of Radiology, Academic Medical Center - University of Amsterdam, Amsterdam, Netherlands, 4 Department of Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 5 Department of Surgery, Academic Medical Center - University of Amsterdam, Amsterdam, Netherlands, 6 Department of Radiation Oncology, Academic Medical Center - University of Amsterdam, Amsterdam, Netherlands

Breathing and peristaltic motions make reliable quantification of DCE-MRI of the pancreas difficult. Here we present an approach to minimize the effects of movement on the quantification of DCE-MRI of the pancreas. Three patients with proven pancreatic cancer were scanned with our 3T DCE-MRI protocol. Images at expiration were selected and registered. Quantification was performed with a two compartment model. Ktrans maps after motion correction showed better correlation with anatomical structures. A larger patient group will show if motion correction favours the capability of DCE-MRI to discriminate between tumour and healthy tissue and if it increases reproducibility between scans.

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