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Abstract #3696

Intraoperative assessment of cerebrovascular reserve capacity during tumor resection with BOLD fMRI

Marco Piccirelli 1 , Oliver Bozinov 2 , Jan-Karl Burkhardt 2 , Roman Kocian 3 , Marian C. Neidert 2 , Antonios Valavanis 1 , Luca Regli 2 , Athina Pangalu 1 , and Jorn Fierstra 2

1 Neuroradiology, University Hospital Zurich, Zurich, ZH, Switzerland, 2 Neurosurgery, University Hospital Zurich, ZH, Switzerland, 3 Anesthesiology, University Hospital Zurich, ZH, Switzerland

Cerebrovascular reserve capacity (CVR) is a useful clinical risk assessment tool for ischemia. Application to brain tumors has a very interesting potential due to the correlation between increased vascularity and tumor malignancy. Further, intraoperative CVR mapping should impact on patient management and guide surgical intervention, by assessing the effectiveness of surgery for brain tumors inducing vascular remodeling. We demonstrate the feasibility of CVR determination with MR during surgical tumor resection on 8 anesthetized patients and illustrate very different vascular responses to surgery. Such spatial information helps to better understand tumor hemodynamics and determine tumor borders.

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