Abstract #3695
Trans-catheter Perfusion MRI for Image-Guided Intraarterial Delivery of Therapeutic Agents to Target-Specific Brain Regions
Piotr Walczak 1,2 , Miroslaw Janowski 1,2 , Jeff WM Bulte 1,2 , and Monica Pearl 3
1
Radiology, Johns Hopkins University,
Baltimore, MD, United States,
2
Institute
for Cell Engineering, Johns Hopkins University,
Baltimore, MD, United States,
3
Interventional
Neuroradiology, Johns Hopkins University, Baltimore, MD,
United States
Efficient delivery of therapeutics to the brain
parenchyma is highly desired for several disciplines,
including regenerative medicine and oncology. Advances
in interventional neuroradiology enable safe,
super-selective catheterization of small intracranial
vessels; however, methods for predicting and optimizing
the perfused parenchymal territory remain
uninvestigated. We used DSC-enhanced trans-catheter
perfusion MRI with Feraheme to predict the perfusion
territory prior to intra-arterial (IA) injection of
mannitol for blood brain barrier disruption and stem
cell delivery. DSC perfusion MRI was highly predictive.
This method may aid in improving the efficacy and safety
of IA delivery of therapeutics.
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