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Abstract #3694

Monitoring Bone Remodeling Following MR-Guided High Intensity Focused Ultrasound on MRI and CT in a Swine Model

Matthew Bucknor 1 , Viola Rieke 1 , Loi Do 1 , Sharmila Majumdar 1 , Thomas Link 1 , and Maythem Saeed 1

1 University of California, San Francisco, San Francisco, CA, United States

Both experimental and clinical studies of MRgHIFU for focal bone lesions have demonstrated remodeling of bone in the weeks to months following MRgHIFU, in some instances with apparent new bone growth. The purpose of the current study was to clearly delineate patterns of bone remodeling following MRgHIFU in a porcine model, as a function of sonication energy. In our study, all higher energy ablations demonstrated evidence of new bone density along the cortex, with a subtle focus of osseous density at 3 weeks and a larger focus at 6 weeks. New bone density was not seen at lower energy ablations.

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