Abstract #3694
Monitoring Bone Remodeling Following MR-Guided High Intensity Focused Ultrasound on MRI and CT in a Swine Model
Matthew Bucknor 1 , Viola Rieke 1 , Loi Do 1 , Sharmila Majumdar 1 , Thomas Link 1 , and Maythem Saeed 1
1
University of California, San Francisco, San
Francisco, CA, United States
Both experimental and clinical studies of MRgHIFU for
focal bone lesions have demonstrated remodeling of bone
in the weeks to months following MRgHIFU, in some
instances with apparent new bone growth. The purpose of
the current study was to clearly delineate patterns of
bone remodeling following MRgHIFU in a porcine model, as
a function of sonication energy. In our study, all
higher energy ablations demonstrated evidence of new
bone density along the cortex, with a subtle focus of
osseous density at 3 weeks and a larger focus at 6
weeks. New bone density was not seen at lower energy
ablations.
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