High-resolution localized 2D J-resolved Spectroscopy for Biological Tissues

Localized 2D J-resolved spectroscopy (JRES) enables the complete separation of chemical shift and J coupling information along two different dimensions, which provides a useful tool for assignment of overlapped resonances in metabolite detection of biological tissues. However, conventional 2D JRES approaches usually suffer from field inhomogeneous effects due to macroscopic magnetic susceptibility in biological tissues. In this report, a new pulse sequence based on intermolecular double-quantum coherences (iDQCs) is presented to achieve high-resolution localized 2D J-resolved information for studying metabolites in biological systems, even for in vivo applications.

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