Abstract #3721
Detection of glutamate, glutamine, and glutathione by RF suppression and TE optimization at 7T
Li An 1 , Shizhe Li 1 , James B Murdoch 2 , Maria Ferraris Araneta 1 , Christopher Johnson 1 , and Jun Shen 1
1
National Institute of Mental Health,
National Institutes of Health, Bethesda, MD, United
States,
2
Toshiba
Medical Research Institute USA, Mayfield Village, OH,
United States
A PRESS pulse sequence inserted with a J-suppression RF
pulse was optimized to resolve and measure glutamate,
glutamine, and other metabolites such as glutathione at
7T. Phantom experiments were performed to validate
results obtained from density matrix simulations.
Metabolite concentration ratios were measured in the
frontal lobe grey matter and white matter of eight
healthy volunteers. Glutamate and glutamine
concentrations were found to be significantly higher in
the frontal lobe grey matter than in the frontal lobe
white matter.
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