Abstract #3725
Multi-vendor GABA-edited MRS
Richard Edden 1,2 , Ashley D Harris 1,2 , Nicolaas AJ Puts 1,2 , C John Evans 3 , Laura M Rowland 4 , S Andrea Wijtenburg 4 , and Peter B Barker 1,2
1
Russell H. Morgan Department of Radiology
and Radiological Science, The Johns Hopkins University,
Baltimore, MD, United States,
2
F.M.
Kirby Research Centre, Kennedy Krieger Institute,
Baltimore, MD, United States,
3
CUBRIC,
School of Psychology, Cardiff University, Cardiff,
United Kingdom,
4
Maryland
Psychiatric Research Center, Department of Psychiatry,
University of Maryland, Baltimore, MD, United States
Edited MRS of GABA, the main inhibitory neurotransmitter
in the human brain, is increasingly applied in studies
of normal brain function and disease. In vivo
quantification of GABA is usually achieved either by a
simple integral ratio to Creatine or in institutional
units, neither of which allow the comparison of
quantitative data from different studies. Herein, we
quantify the editing efficiency of GABA and co-editing
ratio of macromolecular signal for GABA-edited sequences
on GE, Philips and Siemens scanners and demonstrate in
vivo that correcting for these sequence-differences
significantly improves agreement between concentration
measures from each vendor.
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