Sensitivity and specificity to quantify changes in human brain glutathione and ascorbate concentrations using short echo-time 1 H MRS at 3 T and 7 T

We determined the accuracy and precision to measure GSH and Asc concentrations in ultra-short echo time spectra when injecting phantom measured GSH and Asc spectra into 5 in vivo human brain spectra acquired at 3 T and 7 T. We found that a change in GSH ≥ 40% is detectable at both fields while a change in Asc can only be quantified at 7 T.

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