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Abstract #3735

Effects of SPREAD on Proton MRSI Spectra of Human Calf Muscle

Zhengchao Dong 1,2 , Feng Liu 1,2 , Yunsuo Duan 1,2 , Alayar Kangarlu 1,2 , and Yudong Zhang 3

1 Columbia University, New York, NY, United States, 2 New York State Psychiatric Institute, New York, NY, United States, 3 Nanjing Normal University, Jiangsu, China

Proton MRSI has been applied for almost twenty years to the in vivo measurement of intramyocellular lipids (IMCL) in muscle. In the present study, we showed that the SPREAD (Spectral Resolution Amelioration by Deconvolution) technique can improve the spectral resolution of proton MRSI data and conducted Monte Carlo simulations to assess how SPREAD improves spectral resolution and the accuracy of spectral fitting.

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