Effects of SPREAD on Proton MRSI Spectra of Human Calf Muscle
Zhengchao Dong 1,2 , Feng Liu 1,2 , Yunsuo Duan 1,2 , Alayar Kangarlu 1,2 , and Yudong Zhang 3
Columbia University, New York, NY, United
York State Psychiatric Institute, New York, NY, United
Normal University, Jiangsu, China
Proton MRSI has been applied for almost twenty years to
the in vivo measurement of intramyocellular lipids
(IMCL) in muscle. In the present study, we showed that
the SPREAD (Spectral Resolution Amelioration by
Deconvolution) technique can improve the spectral
resolution of proton MRSI data and conducted Monte Carlo
simulations to assess how SPREAD improves spectral
resolution and the accuracy of spectral fitting.
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