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Abstract #3736

On the repeatability and required sample sizes of GABA-MRS experiments.

C. John Evans 1 , Nicolaas Puts 2,3 , Richard Edden 2,3 , and David McGonigle 1,4

1 CUBRIC, School of Psychology, Cardiff University, Cardiff, Wales, United Kingdom, 2 Russel H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, MD, United States, 3 FM Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, MD, United States, 4 School of Biosciences, Cardiff University, Cardiff, Wales, United Kingdom

Experiments relating GABA concentrations to individual differences in neuroimaging signals or behavioural measures are challenging due to the small variations in GABA concentration across healthy populations. The aim of this work is to quantify GABA-MRS measurement repeatability (within and between session) in three voxel locations, and to quantify the range of GABA values in a group of healthy controls. These measurements are used in simulations to estimate the required sample sizes for correctly-powered GABA-MRS experiments.

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