Abstract #3736
On the repeatability and required sample sizes of GABA-MRS experiments.
C. John Evans 1 , Nicolaas Puts 2,3 , Richard Edden 2,3 , and David McGonigle 1,4
1
CUBRIC, School of Psychology, Cardiff
University, Cardiff, Wales, United Kingdom,
2
Russel
H. Morgan Department of Radiology and Radiological
Science, Johns Hopkins University, MD, United States,
3
FM
Kirby Center for Functional Brain Imaging, Kennedy
Krieger Institute, MD, United States,
4
School
of Biosciences, Cardiff University, Cardiff, Wales,
United Kingdom
Experiments relating GABA concentrations to individual
differences in neuroimaging signals or behavioural
measures are challenging due to the small variations in
GABA concentration across healthy populations. The aim
of this work is to quantify GABA-MRS measurement
repeatability (within and between session) in three
voxel locations, and to quantify the range of GABA
values in a group of healthy controls. These
measurements are used in simulations to estimate the
required sample sizes for correctly-powered GABA-MRS
experiments.
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