Absolute Quantitative Spectroscopy through Internal Water Referencing with a One-Minute RRAMSC

Relaxometry-based water compartmentalization is the most accurate and precise method for separating brain tissue and cerebral spinal fluid (CSF) water signals in proton MRI and MRS; however, its long acquisition times make the technique one of rare use in quantitative spectroscopy. Here we examine the use of one-minute RRAMSC ( R apid R elaxometry through A cquisition of M ultiple S aturated T ₂ C urves) for calculating brain metabolite concentrations in molal units.

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