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Abstract #3746

α-Fucose increased in the brain of Chronic Pelvic Pain Syndrome patients with inflammation at onset recorded by 2D L-COSY

Scott G Quadrelli 1 , Saadallah Ramadan 1 , Alexander Lin 2 , Jordan D Dimitrikov 3 , and Carolyn Mountford 1,2

1 Center for MR in Health, The University of Newcastle, Newcastle, NSW, Australia, 2 Department of Radiology, Center for Clinical Spectroscopy - Harvard Medical School, Boston, MA, United States, 3 Department of Nephrology, Childrens Hospital Boston and Harvard Medical School, Boston, MA, United States

Chronic Pelvic Pain (CPPS) is a common, troubling and poorly understood chronic pain condition affecting men. This study aimed to characterise changes in free and bound fucose in patients with CPPS using in vivo 2D L-COSY at 3T. We report a statsically significant increase in cross-peak volumes assigned to -fucose of 68%between healthy controls and patients with inflammatory (type IIIB) CPPS. There is a concomitant 105% decrease in the assigned composite cross peak of Thr/Fuc I suggesting an altered pathway.

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