High-resolution heteronuclear NMR spectroscopy based on spatial encoding and coherence transfer

Two dimensional (2D) NMR fulfills a central role in the application of NMR on chemistry, biology and medicine High-resolution heteronuclear NMR spectroscopy is difficult to be obtained in inhomogeneous fields. Based on spatial encoding and spin-echo coherence transfer, we propose a new method to ultrafast achieve high-resolution HSQC spectra and J coupling information in inhomogeneous fields. The results reveal that the new sequence is an attractive way to eliminate the field inhomogeneous broadening with high time efficiency and provides a promising tool for in vivo and in situ high-resolution 2D NMR spectroscopy.

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