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Abstract #3754

First HR-MAS MRS Slice-Localized Spectroscopy (S.L.S.) and (frequency/space) C.S.I. of living drosophila.

Nicolas Joudiou 1 , Fanny Louat 1 , Sandra Mme 1 , Martine Decoville 1 , Vincent Sarou-Kanian 2 , and Jean-Claude Beloeil 1

1 CNRS CBM UPR4301, Orlans, France, 2 CNRS CEMHTI UPR3079, Orlans, France

In addition to the models developed in monkeys and rodents, many human diseases have been successfully modeled in an insect, Drosophila. The aim of our work was to develop very effective non-invasive methods for in vivo study of Drosophila models of neurodegenerative diseases, at metabolome level, such as HR-MAS MRS. We have shown that it is possible to obtain semi-localized MRS spectra (head, thorax, abdomen) of alive drosophilae by using HR-MAS technique associated with rotating magnetic field gradients and very high magnetic field (17.6T). Applications to the study of mutants up101 will be shown. Studies on neurodegenerative flies models are ongoing.

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