TO DIFFERENTIATE GLUTAMINE FROM GLUTAMATE IN HEPATIC ENCEPHALOPATHY BY TWO-DIMENSIONAL (2D) LOCALIZED CORRELATED SPECTROSCOPY (L-COSY) COMBINED WITH PROFIT QUANTITATION

Brain energy metabolism is believed to be disturbed in cirrhotic patients with hepatic encephalopathy (HE). Ammonia is a neurotoxin and causes increased conversion of glutamate to glutamine. Previous work has shown the important role of MRS in diagnosing and monitoring patients with metabolic disorders. In the one-dimensional (1D) proton MRS, it is very difficult to separate the resonances of glutamate from glutamine and quite often the two are reported together as Glx. In the two-dimensional (2D) localized correlated spectroscopy (L-COSY), additional spectral dimension will be used to separate the overlapping multiplets. The major goal of this study is to review the role of 2D-L-COSY combined with a prior knowledge fitting (ProFit) algorithm in separating glutamine from glutamate in HE patients.

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