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Abstract #3762

13 C MRS of Human Brain at 7T Using Low Power Stochastic Proton Decoupling

Shizhe Li 1 , Li An 2 , Maria Ferraris Araneta 2 , Christopher Johnson 2 , and Jun Shen 1,2

1 Magnetic Resonance Spectroscopy Core Facility, National Institutes of Health, Bethesda, Maryland, United States, 2 Molecular Imaging Branch, National Institutes of Health, Maryland, United States

Feasibility of performing carboxylic/amide 13 C MRS using low RF power stochastic proton decoupling at 7 Tesla is demonstrated. Significant improvement in spectral resolution was achieved as compared to previous 3 Tesla studies. As a result, The GABA C1 signal is clearly resolved from the nearby dominant glutamate C5 signal. Aspartate C1 and glutamine C1 are also resolved. These result warrants further optimization of this technique to improve spectral resolution and sensitivity for studying brain energy metabolism and neurotransmission.

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