Abstract #3762
13 C MRS of Human Brain at 7T Using Low Power Stochastic Proton Decoupling
Shizhe Li 1 , Li An 2 , Maria Ferraris Araneta 2 , Christopher Johnson 2 , and Jun Shen 1,2
1
Magnetic Resonance Spectroscopy Core
Facility, National Institutes of Health, Bethesda,
Maryland, United States,
2
Molecular
Imaging Branch, National Institutes of Health, Maryland,
United States
Feasibility of performing carboxylic/amide
13
C
MRS using low RF power stochastic proton decoupling at 7
Tesla is demonstrated. Significant improvement in
spectral resolution was achieved as compared to previous
3 Tesla studies. As a result, The GABA C1 signal is
clearly resolved from the nearby dominant glutamate C5
signal. Aspartate C1 and glutamine C1 are also resolved.
These result warrants further optimization of this
technique to improve spectral resolution and sensitivity
for studying brain energy metabolism and
neurotransmission.
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