In vivo Chemical Shift Imaging of 5-Fluorouracil and its Metabolites
Jordan A. Lovis 1,2 , Matthew S. Fox 2 , Iain K. Ball 2 , Tao Li 2 , Marcus J. Couch 1,2 , and Mitchell S. Albert 1,2
Lakehead University, Thunder Bay, Ontario,
Bay Regional Research Institute, Thunder Bay, Ontario,
After several decades of use, 5-Fluorouracil (5-FU)
remains one of the most heavily used cytotoxic drugs for
treatment of cancer. Over the last 20 years, an
increased understanding of 5-FUs mechanism of action
has led to an increase in its anticancer activity.
Despite these advances, drug resistance remains a
significant limitation in clinical use. The purpose of
this study was to map 5-FU and its metabolites
distribution in healthy rats using 19F CSI in a 3T
clinical whole-body scanner. These studies may yield
information with respect to drug resistance, thereby
facilitating personalized treatment.
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