IN
)
determines in what exchange regime diffusion-weighted MR
data should be interpreted. We have determined
IN
for
microbead-adherent cultures of rat cerebral cortical
neurons and astrocytes: 0.88
0.24
s for neurons and 0.66
0.17
s for astrocytes. Upon oxygen-glucose-deprivation, a
rapid
IN
decrease
was observed: 0.48
0.07
s and 0.18
0.04
s, respectively. Diffusion times used in clinical
studies of normal subjects place them in the
slow-exchange regime. The non-negligible difference
between neuron and astrocyte
IN
,
especially in injured cells, should be taken into
account in the analysis of time-scale-sensitive data.
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Keywords