Meeting Banner
Abstract #3768

Neuroprotective effect of Lactoferrin following inflammatory injury in the developing rat brain assessed by high-field 1 H-MR Spectroscopy

Yohan van de Looij 1,2 , Vanessa Ginet-Puyal 1 , Rolf Gruetter 2,3 , Petra S Hppi 1 , and Stphane V Sizonenko 1

1 Division of Child Growth and Development, University of Geneva, Geneva, GE, Switzerland, 2 Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, VD, Switzerland, 3 Department of Radiology, University of Geneva and Lausanne, Geneva and Lausanne, GE and VD, Switzerland

Lactoferrin (Lf) is an iron-binding glycoprotein secreted in milk known as antioxydant, anti-inflammatory and antimicrobial. The aim of this work was to assess by 1H-MRS neuroprotective effects of Lf during lactation on 3 days-old pup rats (corresponding to human preterm born at 24-28 weeks of gestation) injected with Lipopolysaccharide (LPS) in the corpus callosum. Results show a partial neuroprotection of Lf supplemented in food during lactation following LPS exposure with less compromised metabolism and reduced ventriculomegaly.

This abstract and the presentation materials are available to members only; a login is required.

Join Here