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Abstract #3769

In vivo 9.4T 1H MRS for evaluation of brain metabolic changes in the Ts65Dn mouse model for Down syndrome

Sandra Mme 1 , Frederic Szeremeta 1 , Patricia Lopes-Pereira 2 , Jean-Claude Beloeil 1 , William Mme 1 , and Yan Hrault 3

1 CNRS CBM UPR4301, Orlans, France, 2 CNRS TAAM UPS44, Orlans, France, 3 CNRS UMR7104, UMR964, Strasbourg, France

Down Syndrom (human trisomy 21) is a chromosomal abnormality characterized by the presence of an additional copy of some genes on chrosome 21. This pathology is characterized by a set of behavioural, morpholical and metabolic alterations. Ts65Dn model is the most widely studied mice model for DS.. Some studies have been performed on Ts65Dn mice on the hippocampus and the on the cerebellum but never in vivo. The aim of this study was to quantify changes in brain metabolites concentrations for TS65Dn mice compared to control mice with 9.4T Magnetic Resonance Spectroscopy (MRS).

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