Abstract #3769
In vivo 9.4T 1H MRS for evaluation of brain metabolic changes in the Ts65Dn mouse model for Down syndrome
Sandra Mme 1 , Frederic Szeremeta 1 , Patricia Lopes-Pereira 2 , Jean-Claude Beloeil 1 , William Mme 1 , and Yan Hrault 3
1
CNRS CBM UPR4301, Orlans, France,
2
CNRS
TAAM UPS44, Orlans, France,
3
CNRS
UMR7104, UMR964, Strasbourg, France
Down Syndrom (human trisomy 21) is a chromosomal
abnormality characterized by the presence of an
additional copy of some genes on chrosome 21. This
pathology is characterized by a set of behavioural,
morpholical and metabolic alterations. Ts65Dn model is
the most widely studied mice model for DS.. Some studies
have been performed on Ts65Dn mice on the hippocampus
and the on the cerebellum but never in vivo. The aim of
this study was to quantify changes in brain metabolites
concentrations for TS65Dn mice compared to control mice
with 9.4T Magnetic Resonance Spectroscopy (MRS).
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