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Abstract #3770

1 H MRS to investigate the hepatic profile of GLUT2 -/- mice

Ana Francisca Soares 1 , Hongxia Lei 2,3 , Frdric Preitner 4 , Bernard Thorens 4 , and Rolf Gruetter 1,5

1 LIFMET, EPFL, Lausanne, Vaud, Switzerland, 2 CIBM-AIT, EPFL, Vaud, Switzerland, 3 University of Geneva, Geneva, Switzerland, 4 Institute of Pharmacology and Toxicology, University of Lausanne, Vaud, Switzerland, 5 University of Lausanne, Vaud, Switzerland

We performed 1 H MRS at 14.1T in the liver of GLUT2 -/- and wild-type (WT) mice. Improved spectral resolution allowed identifying peaks from the lipid resonances, choline containing compounds, taurine and glycogen in WT mice. Performing the same measurements in GLUT2 -/- mice revealed a strong contribution from carbohydrates, notably glucose, to the 1 H MR liver spectrum. Also a reduced lipid content was detected by 1 H MRS in those mice. The characterization of the hepatic profile by 1 H MRS in GLUT2 -/- mice is of great value to address changes in the main energy fuels in the liver longitudinally.

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