Abstract #3770
1 H MRS to investigate the hepatic profile of GLUT2 -/- mice
Ana Francisca Soares 1 , Hongxia Lei 2,3 , Frdric Preitner 4 , Bernard Thorens 4 , and Rolf Gruetter 1,5
1
LIFMET, EPFL, Lausanne, Vaud, Switzerland,
2
CIBM-AIT,
EPFL, Vaud, Switzerland,
3
University
of Geneva, Geneva, Switzerland,
4
Institute
of Pharmacology and Toxicology, University of Lausanne,
Vaud, Switzerland,
5
University
of Lausanne, Vaud, Switzerland
We performed
1
H
MRS at 14.1T in the liver of GLUT2
-/-
and
wild-type (WT) mice. Improved spectral resolution
allowed identifying peaks from the lipid resonances,
choline containing compounds, taurine and glycogen in WT
mice. Performing the same measurements in GLUT2
-/-
mice
revealed a strong contribution from carbohydrates,
notably glucose, to the
1
H
MR liver spectrum. Also a reduced lipid content was
detected by
1
H
MRS in those mice. The characterization of the hepatic
profile by
1
H
MRS in GLUT2
-/-
mice
is of great value to address changes in the main energy
fuels in the liver longitudinally.
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