Abstract #3773
Cortical Proton MR Spectroscopic Imaging Abnormalities in a Macaque Model of NeuroAIDS
William E. Wu 1 , Assaf Tal 1 , James S. Babb 1 , Eva-Maria Ratai 2 , R. Gilberto Gonzalez 2 , and Oded Gonen 1
1
Radiology, New York University School of
Medicine, New York, New York, United States,
2
Neuroradiology,
Massachusetts General Hospital, Athinoula A. Martinos
Center for Biomedical Imaging, Charlestown,
Massachusetts, United States
As ~40% of HIV-infected persons experience
neurocognitive decline, we test whether proton MR
spectroscopic imaging can detect early metabolic
abnormalities in the cerebral cortex of an accelerated
(CD8+ T-lymphocyte depleted) simian immunodeficiency
virus-infected macaque model of neuroAIDS. Mean pre
infection concentrations of glial markers, myo-inositol,
creatine and choline: 5.80.9, 7.20.4 and 0.90.1mM
increased 28% (p=0.06), 15% and 10% (both ps0.05) four
to six weeks post-infection, while neuronal marker,
N-acetylaspartate, remained unchanged (7.00.6 to
7.30.8mM). Taken together with previous studies, these
findings suggest treatment regimens aimed at reducing
cortical gliosis may reduce the risk of
neurodegeneration and its associated neurocognitive
impairments.
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