Abstract #3774
Measurement of Lactate Concentrations in the Breast Mammary Tumors Using Selective Multiple Quantum Coherence Editing Sequence at 4.7T
Sunitha Thakur 1 , Sanjay Annarao 2 , Louisa Bokacheva 3 , and Junh Hun Oh 4
1
Medical Physics, Memorial Sloan Kettering
Cancer Center, New York, NY, United States,
2
Memorial
Sloan-Kettering Cancer Center, New York, NY, United
States,
3
Medical
Physics, Memorial Sloan-Kettering Cancer Center, NY,
United States,
4
Memorial
Sloan-Kettering Cancer Center, NY, United States
The purpose of this study is to measure lactate
concentrations, [Lac] in breast mammary tumors (MCF7,
BT474, MDA231, and MDA435) with contrasting growth
rates, tumor aggressiveness, and metastatic risk. In
this work, we implemented the SS-SelMQC using higher
order binomial pulses (SS1-SelMQC) for lactate detection
as well as T1- and T2- versions of SS1-SelMQC. The [Lac]
in tumors were measured at different tumor volumes. In
all four tumor types, the [Lac] was found to be higher
at tumor volume (100-200 mm
3
), and as tumor
volume increases, [Lac] tend to decrease. No significant
differences in [Lac] were found among different models.
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